Karen Sue Middleton, 70, of Lebanon, OH, passed away on September 21, 2021, with her family at her side. She was the beloved mother of Annie Middleton and Duane (Terica) Middleton; loving grandmother of Madison Evans, Trenton Middleton, and Hunter York; dear sister of Sandra Parker, Kathy Watkins, Diana Watkins, Betty Ann Temperman, and Robert Watkins, Jr.; proud aunt to numerous nieces and nephews. Karen was preceded in death by her parents, Robert Lee and Gloria Rose (nee Hoffman) Watkins and her sister, Mary Lou Kibler. In lieu of flowers, memorial donations may be directed to the Alzheimers Association of Greater Cincinnati644 Linn St. Suite 1026, Cincinnati, OH 45203. A memorial service will be held at the convenience of the family.